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-synuclein, that is a key component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, and that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) stress, recommend that dysfunction with the intracellular proteinase units, including ubiquitin-proteasome system or lysosomal procedure, which eliminates unwanted harmful prote
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